The Ais Indians were a tribe of eastern Florida, closely connected with the
Their language was never recorded. Some ethnologists have guessed that it may have been related
to Calusa, based on stories that people
from the two tribes could communicate with each other. Like the Calusa, the Ais were devastated by
European diseases. Some of the survivors were probably sent to Cuba with the Calusas and Tequestas, while
others may have merged with other Floridian Indians and eventually joined the
There was also a Caddoan band in Texas known as "Ais," unrelated to the Florida tribe. You can learn
more about the Texan Ais band here.
Alternate spellings that have been used for the Florida Ais have been Ays and Ys.