The Opelousa Indians were a small tribe of central Louisiana, relatives of the Atakapas.
The Opelousas have not existed as a tribe since the late 1700's, when they were ravaged by an epidemic. Most of the survivors are said to have merged
with the Atakapa tribe, who were also victims of the same epidemic.
There are no remaining records of the Opelousa language, but it was probably a Gulf language.
8th-century Indian agent John Sibley reported that Opelousa was distinct from Atakapa and that many Opelousas were bilingual in the two languages.